Background: Lobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking.
Objectives: The objective of this review was to assess the effects of lobeline on long term smoking cessation.
Search strategy: We searched the Cochrane Tobacco Addiction Group trials register.
Selection criteria: Randomized trials comparing lobeline to placebo or an alternative therapeutic control, which reported smoking cessation with at least six months follow-up.
Data collection and analysis: We extracted data in duplicate on the type of subjects, the dose and form of lobeline, the outcome measures, method of randomisation, and completeness of follow-up.
Main results: We identified no trials meeting the full inclusion criteria including long term follow-up.
Reviewer's conclusions: There is no evidence available from long term trials that lobeline can aid smoking cessation.