No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status

J Appl Physiol (1985). 2000 May;88(5):1571-5. doi: 10.1152/jappl.2000.88.5.1571.


Several studies have reported that the insertion (I) allele of the angiotensin-converting enzyme (ACE) I/deletion (D) polymorphism is associated with enhanced responsiveness to endurance training and is more common in endurance athletes than in sedentary controls. We tested the latter hypothesis in a cohort of 192 male endurance athletes with maximal oxygen uptake >/=75 ml. kg(-1). min(-1) and 189 sedentary male controls. The ACE ID polymorphism in intron 16 was typed with the three-primer polymerase chain reaction method. Both the genotype (P = 0.214) and allele (P = 0.095) frequencies were similar in the athletes and the controls. Further analyses in the athletes revealed no excess of the I allele among the athletes within the highest quartile (> 80 ml. kg(-1). min(-1)) or decile (>83 ml. kg(-1). min(-1)) of maximal oxygen uptake. These data from the GENATHLETE cohort do not support the hypothesis that the ACE ID polymorphism is associated with a higher cardiorespiratory endurance performance level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Cohort Studies
  • DNA Transposable Elements*
  • Gene Deletion*
  • Genotype
  • Humans
  • Male
  • Oxygen Consumption
  • Peptidyl-Dipeptidase A / genetics*
  • Physical Endurance / physiology*
  • Polymorphism, Genetic / genetics*
  • Reference Values
  • Sports*


  • DNA Transposable Elements
  • Peptidyl-Dipeptidase A