Segregation analysis of serum uric acid in the NHLBI Family Heart Study

Hum Genet. 2000 Mar;106(3):355-9. doi: 10.1007/s004390000243.

Abstract

Segregation analysis was performed on the serum uric acid measurements from 523 randomly ascertained Caucasian families from the NHLBI Family Heart Study. Gender-specific standardized residuals were used as the phenotypic variable in both familial correlation and segregation analysis. Uric acid residuals were adjusted for age, age2, age3, body mass index (kg/m2), creatinine level, aspirin use (yes/no), total drinks (per week), HOMA insulin resistance index [(glucose * insulin)/22.5], diuretic use (yes/no), and triglyceride level. Sibling correlations (r=0.193) and parent-offspring correlations (r=0.217) were significantly different from zero, but these two familial correlations were not significantly different from one another. After adjustment for covariates, the heritability estimate for serum uric acid was 0.399. Segregation analysis rejected the "no major gene" model but was unable to discriminate between an "environmental" and a "Mendelian major gene" model. These results support the hypothesis that uric acid is a multifactorial trait possibly influenced by more than one major gene, modifying genes, and environmental factors.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arteriosclerosis / epidemiology
  • Arteriosclerosis / genetics
  • Cohort Studies
  • Coronary Disease / blood
  • Coronary Disease / epidemiology
  • Coronary Disease / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Nuclear Family
  • Parents
  • Risk Factors
  • Statistics as Topic
  • Uric Acid / blood*
  • White People

Substances

  • Uric Acid