Nasal natural killer cell lymphoma in a post-renal transplant patient

Transplantation. 2000 Apr 15;69(7):1501-3. doi: 10.1097/00007890-200004150-00049.


Posttransplant lymphoproliferative disorders in organ allograft recipients are most commonly of B-cell origin and only occasionally of T-cell origin. We present here a case of nasal natural killer cell lymphoma associated with Epstein-Barr virus that occurred in a recipient of a renal transplant 4 years posttransplantation. Immunohistochemically, the lymphoma cells showed CD2-, surface CD3-, cytoplasmic CD3E+, CD56+, CD57-, CD16-, and CD43+ phenotype. Analyses of T-cell receptor beta and gamma genes showed germ line configurations. EBER-1 was detectable in the lymphoma cells. The patient was diagnosed as having natural killer cell lymphoma and was treated with six courses of combination chemotherapy for non-Hodgkin's lymphoma He has been in remission for more than 3 years thereafter. To the best of our knowledge, this is the first report of a posttransplant NK cell lymphoma associated with Epstein-Barr virus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD / analysis
  • Humans
  • Kidney Transplantation*
  • Killer Cells, Natural*
  • Lymphoma, T-Cell / chemistry
  • Lymphoma, T-Cell / diagnosis
  • Lymphoma, T-Cell / etiology*
  • Lymphoma, T-Cell / immunology
  • Magnetic Resonance Imaging
  • Male
  • Nasal Cavity* / pathology
  • Nose Neoplasms / chemistry
  • Nose Neoplasms / diagnosis
  • Nose Neoplasms / etiology*
  • Nose Neoplasms / immunology
  • Postoperative Complications*
  • RNA, Viral / analysis


  • Antigens, CD
  • Epstein-Barr virus encoded RNA 1
  • RNA, Viral