Model-free analysis and permutation tests for allelic associations

Hum Hered. Mar-Apr 2000;50(2):133-9. doi: 10.1159/000022901.

Abstract

In this short report, we address some practical problems in performing likelihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and procedures based on permutation tests are described for marker-marker as well as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Alleles*
  • Genotype
  • Haplotypes
  • Models, Genetic*
  • Software