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. 2000 Apr 29;355(9214):1518-9.
doi: 10.1016/S0140-6736(00)02169-3.

Zonulin, a Newly Discovered Modulator of Intestinal Permeability, and Its Expression in Coeliac Disease

Zonulin, a Newly Discovered Modulator of Intestinal Permeability, and Its Expression in Coeliac Disease

A Fasano et al. Lancet. .

Abstract

We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.

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