Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease

Lancet. 2000 Apr 29;355(9214):1518-9. doi: 10.1016/S0140-6736(00)02169-3.


We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Celiac Disease / metabolism
  • Cholera Toxin / metabolism
  • Cholera Toxin / pharmacology*
  • Endotoxins
  • Fetus
  • Haptoglobins
  • Humans
  • Intestines / drug effects*
  • Macaca mulatta
  • Permeability / drug effects
  • Protein Precursors


  • Endotoxins
  • Haptoglobins
  • Protein Precursors
  • zonulin
  • zonula occludens toxin, Vibrio cholerae
  • Cholera Toxin