Lancet. 2000 Apr 29;355(9214):1531-9. doi: 10.1016/S0140-6736(00)02175-9.


Platelets, derived from megakaryocyte cytoplasm, have a critical role in normal haemostasis, and in thrombotic disorders. The development of megakaryocytes is controlled by thrombopoietin, which binds to c-mpl on the surface of platelets and megakaryocytes. Platelet membrane glycoproteins mediate binding to subendothelial tissue and aggregation into haemostatic plugs. Thrombocytopenia and disorders of platelet function cause petechiae and mucocutaneous bleeding. Drugs causing specific inhibition of platelet function are important in the treatment of cardiovascular and cerebrovascular disease.

Publication types

  • Review

MeSH terms

  • Blood Platelet Disorders / drug therapy
  • Blood Platelet Disorders / physiopathology*
  • Blood Platelets / physiology*
  • Female
  • Humans
  • Platelet Glycoprotein GPIb-IX Complex / physiology
  • Platelet Membrane Glycoproteins*
  • Pregnancy
  • Pregnancy Complications, Hematologic / physiopathology
  • Receptors, Cell Surface / physiology*
  • Thrombopoietin / physiology*


  • Platelet Glycoprotein GPIb-IX Complex
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • glycoprotein receptor GPIb-IX
  • Thrombopoietin