The nucleolus: the magician's hat for cell cycle tricks

Curr Opin Cell Biol. 2000 Jun;12(3):372-7. doi: 10.1016/s0955-0674(00)00102-2.

Abstract

The nucleolus, for decades considered a ribosome factory and site for ribosomal RNA synthesis and processing, has recently acquired new fame. Analyses of proteins important for cell-cycle regulation have shown that this organelle is used to sequester proteins, thereby inhibiting their activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / metabolism
  • Cell Nucleolus / metabolism*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Genes, Fungal
  • Humans
  • Meiosis / physiology
  • Nuclear Proteins*
  • Protein Tyrosine Phosphatases*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-mdm2
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*

Substances

  • CDC14 protein, S cerevisiae
  • Cell Cycle Proteins
  • Fungal Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Saccharomyces cerevisiae Proteins
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Protein Tyrosine Phosphatases