Abstract
The nucleolus, for decades considered a ribosome factory and site for ribosomal RNA synthesis and processing, has recently acquired new fame. Analyses of proteins important for cell-cycle regulation have shown that this organelle is used to sequester proteins, thereby inhibiting their activity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Cycle / physiology*
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Cell Cycle Proteins / metabolism
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Cell Nucleolus / metabolism*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Genes, Fungal
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Humans
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Meiosis / physiology
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Nuclear Proteins*
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Protein Tyrosine Phosphatases*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-mdm2
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins*
Substances
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CDC14 protein, S cerevisiae
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Cell Cycle Proteins
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Fungal Proteins
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Nuclear Proteins
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Proto-Oncogene Proteins
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Saccharomyces cerevisiae Proteins
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2
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Protein Tyrosine Phosphatases