Sister chromatid cohesion: the beginning of a long and beautiful relationship

Curr Opin Cell Biol. 2000 Jun;12(3):297-301. doi: 10.1016/s0955-0674(00)00092-2.


Our understanding of the mechanism of sister chromatid cohesion has advanced significantly with the recent identification and characterization of important regulatory factors, structural factors and chromosomal cohesion sites. These analyses reveal a surprisingly complex mechanism of cohesion that is just beginning to be elucidated and exciting connections between cohesion, cell-cycle regulation and other forms of DNA metabolism.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adhesiveness
  • Animals
  • Cell Cycle
  • Cell Cycle Proteins
  • Chromatids / genetics
  • Chromatids / physiology*
  • Chromatids / ultrastructure
  • Chromosomal Proteins, Non-Histone
  • DNA Replication
  • Fungal Proteins
  • Humans
  • Nuclear Proteins / physiology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae / ultrastructure


  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Fungal Proteins
  • Nuclear Proteins
  • cohesins