Nuclear transport and transcription

Curr Opin Cell Biol. 2000 Jun;12(3):355-60. doi: 10.1016/s0955-0674(00)00100-9.


The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation. In addition, nuclear transport plays a crucial role in regulating the activity of many transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biological Transport, Active
  • Cell Nucleus / metabolism*
  • DNA / genetics
  • DNA / metabolism
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / metabolism
  • Humans
  • NFATC Transcription Factors
  • Nuclear Proteins*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*
  • TATA-Box Binding Protein
  • Transcription Factor TFIIA
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • Tumor Suppressor Protein p53 / metabolism


  • DNA-Binding Proteins
  • Fungal Proteins
  • NFATC Transcription Factors
  • Nuclear Proteins
  • PHO4 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • TATA-Box Binding Protein
  • Transcription Factor TFIIA
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • DNA