Acetylation and chromosomal functions

Curr Opin Cell Biol. 2000 Jun;12(3):326-33. doi: 10.1016/s0955-0674(00)00096-x.


Since the initial discovery of histone acetyltransferases, numerous reports have established that histone acetyltransferases and histone deacetylases regulate transcription by acetylating and deacetylating histones, respectively. Recent studies have focused on the effects of histone acetylation on gene expression regulation during development and the roles of histone hypoacetylation in the maintenance of centromeric structure, X-inactivation and genomic imprinting. Recent findings have also shown that the functions of non-histone proteins can also be regulated by acetylation. Together, these data highlight the importance of acetylation of histones and non-histone proteins in a variety of chromosomal functions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylation
  • Animals
  • Cell Differentiation
  • Centromere / metabolism
  • Chromosomes / genetics*
  • Chromosomes / metabolism*
  • DNA Methylation
  • Dosage Compensation, Genetic
  • Female
  • Gene Expression Regulation
  • Gene Silencing
  • Histones / metabolism*
  • Humans
  • Male
  • Models, Biological
  • Replication Origin
  • Transcription Factors / metabolism


  • Histones
  • Transcription Factors