Dietary factors influencing zinc absorption

J Nutr. 2000 May;130(5S Suppl):1378S-83S. doi: 10.1093/jn/130.5.1378S.


Marginal zinc deficiency and suboptimal zinc status have been recognized in many groups of the population in both less developed and industrialized countries. Although the cause in some cases may be inadequate dietary intake of zinc, inhibitors of zinc absorption are most likely the most common causative factor. Phytate, which is present in staple foods like cereals, corn and rice, has a strong negative effect on zinc absorption from composite meals. Inositol hexaphosphates and pentaphosphates are the phytate forms that exert these negative effects, whereas the lower phosphates have no or little effect on zinc absorption. The removal or reduction of phytate by enzyme (phytase) treatment, precipitation methods, germination, fermentation or plant breeding/genetic engineering markedly improves zinc absorption. Iron can have a negative effect on zinc absorption, if given together in a supplement, whereas no effect is observed when the same amounts are present in a meal as fortificants. Cadmium, which is increasing in the environment, also inhibits zinc absorption. The amount of protein in a meal has a positive effect on zinc absorption, but individual proteins may act differently; e.g., casein has a modest inhibitory effect of zinc absorption compared with other protein sources. Amino acids, such as histidine and methionine, and other low-molecular-weight ions, such as EDTA and organic acids (e.g., citrate), are known to have a positive effect on zinc absorption and have been used for zinc supplements. Knowledge about dietary factors that inhibit zinc absorption and about ways to overcome or remove these factors is essential when designing strategies to improve the zinc nutrition of vulnerable groups.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Amino Acids / pharmacology
  • Biological Availability
  • Cadmium / pharmacology
  • Copper / pharmacology
  • Diet*
  • Dietary Proteins / pharmacology*
  • Humans
  • Intestinal Absorption / drug effects*
  • Iron, Dietary / pharmacology
  • Male
  • Phytic Acid / administration & dosage
  • Phytic Acid / analogs & derivatives
  • Phytic Acid / pharmacology*
  • Zinc / deficiency
  • Zinc / metabolism
  • Zinc / pharmacokinetics*


  • Amino Acids
  • Dietary Proteins
  • Iron, Dietary
  • Cadmium
  • Copper
  • Phytic Acid
  • Zinc