Antioxidant alpha-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes

FEBS Lett. 2000 May 4;473(1):24-6. doi: 10.1016/s0014-5793(00)01489-7.

Abstract

We have shown recently that oxidative stress by chronic hyperglycemia damages the pancreatic beta-cells of GK rats, a model of non-obese type 2 diabetes, which may worsen diabetic condition and suggested the administration of antioxidants as a supportive therapy. To determine if natural antioxidant alpha-tocopherol (vitamin E) has beneficial effects on the glycemic control of type 2 diabetes, GK rats were fed a diet containing 0, 20 or 500 mg/kg diet alpha-tocopherol. Intraperitoneal glucose tolerance test revealed a significant increment of insulin secretion at 30 min and a significant decrement of blood glucose levels at 30 and 120 min after glucose loading in the GK rats fed with high alpha-tocopherol diet. The levels of glycated hemoglobin A1c, an indicator of glycemic control, were also reduced. Vitamin E supplementation clearly ameliorated diabetic control of GK rats, suggesting the importance of not only dietary supplementation of natural antioxidants but also other antioxidative intervention as a supportive therapy of type 2 diabetic patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / analysis
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Blood Glucose* / drug effects
  • Body Weight / drug effects
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Dietary Supplements
  • Disease Models, Animal
  • Fasting
  • Glucose / administration & dosage
  • Glucose / metabolism
  • Glucose Tolerance Test
  • Glycated Hemoglobin A / metabolism
  • Insulin / blood
  • Male
  • Pancreas / chemistry
  • Pancreas / drug effects
  • Pancreas / pathology
  • Pancreas / physiopathology
  • Rats
  • Rats, Inbred Strains
  • Vitamin E / administration & dosage
  • Vitamin E / analysis
  • Vitamin E / pharmacology
  • Vitamin E / therapeutic use*

Substances

  • Antioxidants
  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • Vitamin E
  • Glucose