Towards a molecular understanding of cytokinesis

Trends Cell Biol. 2000 Jun;10(6):228-37. doi: 10.1016/s0962-8924(00)01747-5.


In this review, we focus on recent discoveries regarding the molecular basis of cleavage furrow positioning and contractile ring assembly and contraction during cytokinesis. However, some of these mechanisms might have different degrees of importance in different organisms. This synthesis attempts to uncover common themes and to reveal potential relationships that might contribute to the biochemical and mechanical aspects of cytokinesis. Because the information about cytokinesis is still fairly rudimentary, our goal is not to present a definitive model but to present testable hypotheses that might lead to a better mechanistic understanding of the process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / physiology*
  • Eukaryotic Cells / cytology*
  • Mitosis / physiology*


  • Cell Cycle Proteins