Mitochondrial control of cell death

Nat Med. 2000 May;6(5):513-9. doi: 10.1038/74994.


In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis / physiology*
  • Disease
  • Intracellular Membranes / physiology*
  • Mitochondria / physiology*
  • Models, Biological
  • Permeability