Characterization of a novel polycystic kidney rat model with accompanying polycystic liver

Exp Anim. 2000 Jan;49(1):51-5. doi: 10.1538/expanim.49.51.


A polycystic kidney rat model is being established from a Crj:CD (SD) rat strain. Unlike existing animal models of polycystic kidney disease, this mutant rat has a completely polycystic liver. Mating experiments revealed that the phenotype is controlled by an autosomal recessive gene. We propose that this gene be tentatively called the "rpc" gene.

MeSH terms

  • Animals
  • Crosses, Genetic
  • Cysts / genetics*
  • Cysts / pathology
  • Disease Models, Animal*
  • Female
  • Liver Diseases / genetics*
  • Liver Diseases / pathology
  • Male
  • Phenotype
  • Polycystic Kidney Diseases / genetics*
  • Polycystic Kidney Diseases / pathology
  • Rats
  • Rats, Mutant Strains
  • Sex Characteristics