The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans

Int J Obes Relat Metab Disord. 2000 Apr;24(4):522-4. doi: 10.1038/sj.ijo.0801210.


Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-gamma2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P= 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Body Mass Index
  • Female
  • Humans
  • Leptin / genetics
  • Male
  • Mexican Americans / genetics*
  • Obesity / genetics*
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Texas
  • Transcription Factors / genetics*
  • Whites / genetics*


  • Leptin
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors