An encore for ribosome biogenesis in the control of cell proliferation

Nat Cell Biol. 2000 May;2(5):E71-2. doi: 10.1038/35010581.


Although the importance of cell growth for cell-cycle progression has been recognized for thirty years, the molecular basis of this relationship is poorly understood. However, researchers have begun to tease apart these two processes in model systems. This commentary focuses on one potential mechanism by which ribosome biogenesis antagonizes cell-cycle progression until the cell has grown to an adequate size.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology
  • Cell Size / physiology
  • Oocytes / cytology*
  • Oocytes / physiology*
  • Ribosomes / physiology*