R-factor Mediated Beta-Lactamase Production by Haemophilus Influenzae

J Med Microbiol. 1975 Aug;8(3):437-41. doi: 10.1099/00222615-8-3-437.

Abstract

Production of beta-lactamase by 15 strains of Haemophilus influenzae has been investigated. All the strains produce a constitutive beta-lactamase, which readily hydrolyses penicillin G, ampicillin, and cephaloridine. The beta-lactamase produced by these strains is indistinguishable from the type-IIIa enzyme commonly found in strains of Escherichia coli. The beta-lactamase gene has been transferred from the enzyme-producing strains of Haemophilus to strains of H. parainfluenzae and a strain of E. coli.

MeSH terms

  • Amidohydrolases / biosynthesis*
  • Ampicillin / metabolism
  • Anti-Bacterial Agents / pharmacology
  • Cephaloridine / metabolism
  • Cephalosporinase / biosynthesis*
  • Conjugation, Genetic
  • Haemophilus influenzae / drug effects
  • Haemophilus influenzae / enzymology*
  • Hydrolysis
  • Penicillin G / metabolism
  • Penicillin Resistance*
  • Penicillinase / biosynthesis*
  • R Factors*
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • Ampicillin
  • Amidohydrolases
  • Cephalosporinase
  • Penicillinase
  • Cephaloridine
  • Penicillin G