The functions of circulatory polymorphonuclear leukocytes in diabetic patients with and without diabetic triopathy

Life Sci. 2000 Mar 31;66(19):1861-70. doi: 10.1016/s0024-3205(00)00509-9.

Abstract

We determined circulatory polymorphonuclear leukocytes (PMN) functions of superoxide anion production, adhesion and aggregation in 38 type 2 diabetic patients with and without diabetic triopathy. Tumor necrosis factor (TNF)-alpha-stimulated superoxide production and N-formyl-methionyl-leucyl-phenylalanine (FMLP)-stimulated aggregation in diabetic patients with triopathy were significantly greater than those in diabetics without triopathy. The more diabetic complications existed, the more TNF-alpha-stimulated superoxide was produced by PMN. These results suggest that the activated PMN contributes to a progression of diabetic triopathy in type 2 diabetic patients.

Publication types

  • Clinical Trial

MeSH terms

  • Cell Adhesion / physiology
  • Cell Aggregation / physiology
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology*
  • Diabetic Nephropathies / metabolism
  • Diabetic Nephropathies / pathology*
  • Diabetic Neuropathies / metabolism
  • Diabetic Neuropathies / pathology*
  • Diabetic Retinopathy / metabolism
  • Diabetic Retinopathy / pathology*
  • Female
  • Glycated Hemoglobin A / metabolism
  • Granulocytes / drug effects
  • Granulocytes / metabolism
  • Humans
  • Lipid Peroxides / blood
  • Male
  • Middle Aged
  • Neutrophils / physiology*
  • Oxygen Consumption / physiology
  • Superoxides / metabolism
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Glycated Hemoglobin A
  • Lipid Peroxides
  • Tumor Necrosis Factor-alpha
  • Superoxides