Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis

Histol Histopathol. 2000 Apr;15(2):587-91. doi: 10.14670/HH-15.587.


CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / immunology*
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Humans
  • Immunophenotyping
  • Leukocyte Common Antigens / immunology*
  • Leukocyte Common Antigens / metabolism
  • Protein Isoforms / immunology
  • Protein Isoforms / metabolism
  • T-Lymphocytes / immunology
  • Tissue Distribution
  • fas Receptor / immunology


  • Protein Isoforms
  • fas Receptor
  • Leukocyte Common Antigens