Apoptosis and chemoresistance in human ovarian cancer: is Xiap a determinant?

Biol Signals Recept. Mar-Apr 2000;9(2):122-30. doi: 10.1159/000014631.

Abstract

Cisplatin-induced apoptosis in epithelial ovarian cancer cells is in part a consequence of suppressed Xiap expression and upregulation of the Fas/FasL system. Changes in the expression of these 'cell death' and 'cell survival' genes lead to activation of caspase-3, and cleavage of MDM2 and FAK. Failure of cancer cells to maintain a balance in the expression of these genes in favor of apoptotic cell death may be an important factor of chemoresistance. Xiap may be a novel target for gene therapy of human ovarian epithelial cancer and, dependent on P53 status, expression of Xiap antisense alone or in combination with wild-type P53 sense may offer a new approach for the treatment of the chemoresistant cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Apoptosis / physiology*
  • Cisplatin / therapeutic use*
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / physiopathology*
  • Proteins / physiology*
  • X-Linked Inhibitor of Apoptosis Protein

Substances

  • Antineoplastic Agents
  • Proteins
  • X-Linked Inhibitor of Apoptosis Protein
  • XIAP protein, human
  • Cisplatin