Human papillomavirus in head and neck carcinomas: prevalence, physical status and relationship with clinical/pathological parameters

Anticancer Res. Mar-Apr 2000;20(2B):1301-5.

Abstract

The association of human papillomavirus (HPV) infection to head and neck squamous cell carcinomas was evaluated in 66 patients affected by tumours of the oral cavity (n = 38), the tonsil (n = 4), the pharynx (n = 2), and the larynx (n = 22). HPV DNA was detected by PCR-based assays, recognizing late and early genes. Twenty-four cases were HPV infected (36.4%), mostly by high and/or intermediate risk types. HPV 16 was integrated in 7/12 positive tumours without site-specificity. HPV infection was not related to age, gender, tumour stage, differentiation grade, and use of alcohol and/or tobacco. The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcohol Drinking
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / virology*
  • DNA, Viral / analysis
  • Female
  • Head and Neck Neoplasms / complications
  • Head and Neck Neoplasms / epidemiology
  • Head and Neck Neoplasms / pathology
  • Head and Neck Neoplasms / virology*
  • Humans
  • Laryngeal Neoplasms / complications
  • Laryngeal Neoplasms / virology
  • Male
  • Middle Aged
  • Mouth Neoplasms / complications
  • Mouth Neoplasms / virology
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / epidemiology
  • Pharyngeal Neoplasms / complications
  • Pharyngeal Neoplasms / virology
  • Polymerase Chain Reaction
  • Prevalence
  • Risk Factors
  • Smoking
  • Tonsillar Neoplasms / complications
  • Tonsillar Neoplasms / virology
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / diagnosis*
  • Tumor Virus Infections / epidemiology

Substances

  • DNA, Viral