Estrogen replacement therapy and gallbladder disease in postmenopausal women

Menopause. 2000 May-Jun;7(3):162-7. doi: 10.1097/00042192-200007030-00006.


Objective: To examine the role of estrogen replacement therapy on the development of gallbladder disease in postmenopausal women.

Design: Systematic review of the English literature was conducted. All studies that addressed the association between hormone replacement therapy and gallbladder disease published from 1970 to the present were reviewed.

Results: Seven observational studies, two clinical trials, two case series, and one nonrandomized and three randomized investigations were reviewed. The results of each study were reported and analyzed.

Conclusions: Estrogen replacement therapy in postmenopausal women increased the chances for gallstone formation.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Bile / drug effects
  • Cholelithiasis / chemistry
  • Cholelithiasis / etiology
  • Cholesterol / analysis
  • Estrogen Replacement Therapy / adverse effects*
  • Female
  • Gallbladder Diseases / etiology*
  • Humans
  • Postmenopause*
  • Risk Factors


  • Cholesterol