The proinflammatory transcription factor NFkappaB: a potential target for novel therapeutical strategies

Cell Biol Toxicol. 1999;15(6):341-4. doi: 10.1023/a:1007652414175.

Abstract

NFkappaB is a ubiquitous transcription factor involved in the proinflammatory response to cytokines (such as IL-1 or TNF-alpha) and some particular stresses. The unraveling of the molecular mechanisms involved in its activation is quite recent, particularly in the case of IL-1-stimulated cells, but the identification of the molecules involved in this pathway opens new prospects in both pharmacological and toxicological research.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Cytokines / physiology
  • Inflammation Mediators / metabolism*
  • Mice
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism*

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • Inflammation Mediators
  • NF-kappa B