Origin of YAP+ lineages of the human Y-chromosome

Am J Phys Anthropol. 2000 Jun;112(2):149-58. doi: 10.1002/(SICI)1096-8644(2000)112:2<149::AID-AJPA2>3.0.CO;2-M.


We screened a total of 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAP+ chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAP+ chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAP+ lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAP+ lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin and evolution of ancestral and derived YAP+ elements. We analyze the evidence supporting these two hypotheses, and we conclude that the information available does not allow one to decide between the out-of-Asia or out-of-Africa models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa
  • Alu Elements / genetics*
  • Animals
  • Asia
  • Biological Evolution*
  • Genetic Markers
  • Genetics, Population*
  • Hominidae / genetics*
  • Humans
  • Y Chromosome / genetics*


  • Genetic Markers