Abstract
A case history is presented of the occurrence of a high binding capacity for native DNA in the serum of a patient on phenylbutazone. This reverted to normal on stopping the drug. The patient also had a reversible neutropenia and leucopenia, and it is suggested that the high anti-DNA binding capacity was a feature of a drug-induced lupus-like phenomenon.
MeSH terms
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Antibodies* / analysis
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Antibodies, Antinuclear / analysis
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Antistreptolysin / analysis
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Binding Sites / drug effects
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Binding Sites, Antibody
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Humans
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Indomethacin / therapeutic use
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Leukocyte Count
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Leukopenia / chemically induced
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Male
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Middle Aged
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Neutropenia / chemically induced
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Oxyphenbutazone / adverse effects
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Oxyphenbutazone / therapeutic use
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Phenylbutazone / adverse effects*
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Phenylbutazone / therapeutic use
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Spondylitis, Ankylosing / drug therapy
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Spondylitis, Ankylosing / immunology
Substances
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Antibodies
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Antibodies, Antinuclear
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Antistreptolysin
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Phenylbutazone
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Oxyphenbutazone
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Indomethacin