Differences in water diffusion and lactate production in two different types of postinfectious encephalopathy

J Magn Reson Imaging. 2000 May;11(5):559-63. doi: 10.1002/(sici)1522-2586(200005)11:5<559::aid-jmri12>3.0.co;2-c.


We compared two different types of postinfectious encephalopathy using magnetic resonance imaging (MRI), including diffusion-weighted images and MR spectroscopy. Acute disseminated encephalomyelitis (ADEM) and acute necrotizing encephalopathy (ANE) showed different distribution of abnormal intensity areas and different diffusion of water measured by diffusion-weighted imaging (DWI). Proton MR spectroscopy (MRS) showed lactate production in both cases, which returned to a normal range; the rate of increased lactate production was much lower in the ANE case. Water diffusion showed a difference in pathophysiological background between the two encephalopathies, but the lactate elevation observed by proton MRS did not correlate with clinical severity.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Body Water*
  • Brain Chemistry*
  • Brain Diseases / diagnosis
  • Brain Diseases / etiology
  • Brain Diseases / metabolism*
  • Child
  • Echo-Planar Imaging
  • Encephalomyelitis, Acute Disseminated / diagnosis
  • Encephalomyelitis, Acute Disseminated / metabolism*
  • Female
  • Humans
  • Infections / complications*
  • Lactic Acid / analysis*
  • Magnetic Resonance Spectroscopy*
  • Necrosis


  • Lactic Acid