New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures

Org Lett. 2000 Feb 10;2(3):289-92. doi: 10.1021/ol991239r.

Abstract

[reaction: see text] We present two new diffusion-edited NMR experiments, improved DECODES and HETDECODES, that sort the constituents in a mixture by their individual diffusion coefficients. These experiments should allow the partial NMR spectral assignment and cursory structure elucidation of compounds in a complex mixture as an aid in the dereplication of known or nuisance compounds.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biological Factors / chemistry
  • Biological Factors / isolation & purification*
  • Biotechnology
  • Cyanobacteria / chemistry
  • Diffusion
  • Insecticides / chemistry
  • Insecticides / isolation & purification
  • Nuclear Magnetic Resonance, Biomolecular / methods*

Substances

  • Biological Factors
  • Insecticides