Abstract
Children are sensitive to the inflammatory side effects of cardiopulmonary bypass (CPB). Our intention was to investigate if the biocompatibility benefits of heparin-coated CPB circuits apply to children. In 20 operations, 19 children were randomized to heparin-coated (group HC, n = 10) or standard (group C, n = 10) bypass circuits. Plasma levels of acute phase reactants, interleukins, granulocytic proteins and complement factors were measured. All were significantly elevated after CPB. Levels of complement factor C3a (851 (791-959)ng/ml [median with quartiles] in group C, 497 (476-573)ng/ml in group HC, p < 0.001), Terminal Complement Complex (114 (71-130) AU/ml in group C, 35.5 (28.9-51.4) AU/ml in group HC, p < 0.001), and interleukin-6 (570 (203-743) pg/ml in group C, 168 (111-206)pg/ml in group HC, p = 0.005), were significantly reduced in group HC. Heparin-coated CPB circuits improve the biocompatibility of CPB during heart surgery in the paediatric patient population, as reflected by significantly reduced levels of circulating complement factors and interleukin-6.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticoagulants* / pharmacology
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Antithrombin III / metabolism
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Biomarkers / blood
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C-Reactive Protein / metabolism
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Cardiopulmonary Bypass / instrumentation*
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Coated Materials, Biocompatible*
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Complement C3 / antagonists & inhibitors
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Complement C3 / metabolism*
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Complement Membrane Attack Complex / antagonists & inhibitors
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Complement Membrane Attack Complex / metabolism
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Enzyme-Linked Immunosorbent Assay
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Heart Defects, Congenital / blood
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Heart Defects, Congenital / surgery*
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Heparin* / pharmacology
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Humans
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Infant
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Interleukin-10 / blood
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Interleukin-6 / antagonists & inhibitors
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Interleukin-6 / blood*
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Interleukin-8 / blood
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Lactoferrin / blood
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Peptide Hydrolases / metabolism
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Peroxidase / blood
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Prospective Studies
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Treatment Outcome
Substances
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Anticoagulants
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Biomarkers
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Coated Materials, Biocompatible
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Complement C3
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Complement Membrane Attack Complex
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Interleukin-6
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Interleukin-8
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antithrombin III-protease complex
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Interleukin-10
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Antithrombin III
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Heparin
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C-Reactive Protein
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Peroxidase
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Peptide Hydrolases
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Lactoferrin