Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of the mitochondrial DNA?

Biochem Soc Trans. 2000 Feb;28(2):154-9. doi: 10.1042/bst0280154.


The mechanism of mitochondrial transcription is well documented although the method of regulation remains obscure. The mitochondrial transcription-termination complex, mTERF, holds a key position in determining the fate of heavy-strand promotor-initiated transcripts and has been suggested as a candidate in the regulation of mitochondrial DNA (mtDNA) transcription. We report here the first example of a modulation of mTERF-complex binding activity concomitant with a differential mtDNA transcription rate. We suggest that these observations are indicative of a method of intra-organellar transcriptional fine tuning.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytosol / metabolism
  • DNA, Mitochondrial / genetics*
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Mitochondria / genetics*
  • Mitochondria / metabolism*
  • Models, Genetic
  • Protein Binding
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Transfer / genetics
  • RNA, Transfer / metabolism
  • Transcription, Genetic*
  • Tumor Cells, Cultured


  • DNA, Mitochondrial
  • RNA, Messenger
  • RNA, Transfer