Treatment of lymphangiomas of the head and neck in children by intralesional injection of OK-432 (Picibanil)

Clin Otolaryngol Allied Sci. 2000 Apr;25(2):130-4. doi: 10.1046/j.1365-2273.2000.00338.x.


The treatments previously used for lymphangiomas of the head and neck in children-surgery and intralesional injection of sclerosants-are associated with significant morbidity. A new treatment-intralesional injection of OK-432-was used for lymphangiomas of the head and neck in 11 children. The results were total shrinkage in two, marked shrinkage in two, slight shrinkage in five and no response in two. The results were not affected by previous surgery nor by whether aspiration prior to injection was possible. There were no recurrences in those children in whom shrinkage occurred and no child had subsequent surgery following injection. The results of this series support those of previous series showing that OK-432 injection is an effective and safe treatment for lymphangiomas of the head and neck in children.

MeSH terms

  • Adolescent
  • Antineoplastic Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Administration Routes
  • Female
  • Head and Neck Neoplasms / diagnosis
  • Head and Neck Neoplasms / drug therapy*
  • Humans
  • Infant
  • Injections
  • Lymphangioma / diagnosis
  • Lymphangioma / drug therapy*
  • Male
  • Picibanil / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Antineoplastic Agents
  • Picibanil