Cytokinesis in fission yeast: a myosin pas de deux

Microsc Res Tech. 2000 Apr 15;49(2):152-60. doi: 10.1002/(SICI)1097-0029(20000415)49:2<152::AID-JEMT7>3.0.CO;2-7.

Abstract

Cytokinesis in the fission yeast, Schizosaccharomyces pombe consists of two distinct but overlapping events: the assembly and constriction of a cytokinetic actomyosin ring (CAR) and the formation of a cross wall or septum. These two processes must be spatially and temporally coordinated both with each other and with other cell cycle events, most notably spindle formation and anaphase chromosome segregation. In fission yeast, the CAR contains two unusual type II myosins, Myo2, encoded by the gene myo2(+), and Myp2, encoded by myp2(+). The relationship of these two proteins to each other and their relative contribution to CAR assembly and contraction is largely unknown. Here we review what is known about the role of each myosin in cytokinesis and present some new information concerning their regulation and possible physical interaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Cycle Proteins / metabolism
  • Cell Division*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation, Fungal
  • Models, Biological
  • Myosin Heavy Chains*
  • Myosin Type II*
  • Myosin Type V*
  • Myosins / genetics
  • Myosins / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Schizosaccharomyces / cytology*
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces / physiology
  • Schizosaccharomyces pombe Proteins*

Substances

  • Actins
  • Carrier Proteins
  • Cell Cycle Proteins
  • Fungal Proteins
  • MYO2 protein, S cerevisiae
  • MYO2 protein, S pombe
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • CDC7 protein, S cerevisiae
  • cdc7 protein, S pombe
  • Protein-Serine-Threonine Kinases
  • Myosin Type II
  • Myosin Type V
  • Myosin Heavy Chains
  • Myosins