Synaptic plasticity and dynamic modulation of the postsynaptic membrane

C Lüscher; R A Nicoll; R C Malenka; D Muller

doi:10.1038/75714

Synaptic plasticity and dynamic modulation of the postsynaptic membrane

Nat Neurosci. 2000 Jun;3(6):545-50. doi: 10.1038/75714.

Authors

C Lüscher¹, R A Nicoll, R C Malenka, D Muller

Affiliation

¹ Department of Pharmacology (APSIC), CMU, 1, Rue Michel-Servet, Université de Genève, 1211 Geneva 4, Switzerland. christian.luscher@medecine.unige.ch

PMID: 10816309
DOI: 10.1038/75714

Abstract

The biochemical composition of the postsynaptic membrane and the structure of dendritic spines may be rapidly modulated by synaptic activity. Here we review these findings, discuss their implications for long-term potentiation (LTP) and long-term depression (LTD) and propose a model of sequentially occurring expression mechanisms.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cell Size
Dendrites / metabolism*
Long-Term Potentiation / physiology*
Models, Neurological
Nerve Tissue Proteins / metabolism
Neural Inhibition / physiology
Neuronal Plasticity / physiology*
Pseudopodia / metabolism
Receptors, AMPA / metabolism
Signal Transduction / physiology
Synapses / metabolism*
Synaptic Membranes / metabolism*

Substances

Nerve Tissue Proteins
Receptors, AMPA