Interaction of group A streptococci with human plasmin(ogen) under physiological conditions

Methods. 2000 Jun;21(2):165-77. doi: 10.1006/meth.2000.0988.


A series of methods for analyzing the interaction of group A streptococci with the human plasminogen system are described. Examples of group A streptococcal isolates capable of assembling surface plasminogen activator activity when grown in human plasma are presented and the key requirements for this process are evaluated. The stabilities of cell-associated plasmin and plasminogen activator complexes are compared and a model for the interaction of group A streptococci with the plasminogen system in an infected host is presented.

MeSH terms

  • Adult
  • Blotting, Western
  • Fibrinogen / metabolism
  • Fibrinogen / physiology
  • Fibrinolysin / metabolism*
  • Humans
  • Peptide Fragments / metabolism
  • Plasminogen / metabolism*
  • Streptococcal Infections / blood*
  • Streptococcus pyogenes / physiology*
  • Streptokinase / metabolism*


  • Peptide Fragments
  • lys-plasmin
  • Fibrinogen
  • Plasminogen
  • Streptokinase
  • Fibrinolysin