Salmonella enterica serovars Typhimurium and Dublin can lyse macrophages by a mechanism distinct from apoptosis

Infect Immun. 2000 Jun;68(6):3744-7. doi: 10.1128/IAI.68.6.3744-3747.2000.

Abstract

Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Bacterial Proteins / genetics
  • Caspase Inhibitors*
  • Cattle
  • Cell Death*
  • Eukaryotic Cells
  • Macrophages, Alveolar / microbiology*
  • Macrophages, Alveolar / pathology
  • Membrane Proteins / genetics
  • Salmonella enterica / pathogenicity*
  • Salmonella typhimurium / pathogenicity*

Substances

  • Bacterial Proteins
  • Caspase Inhibitors
  • Membrane Proteins
  • invasion protein B, Salmonella typhimurium