Abstract
Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis
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Bacterial Proteins / genetics
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Caspase Inhibitors*
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Cattle
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Cell Death*
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Eukaryotic Cells
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Macrophages, Alveolar / microbiology*
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Macrophages, Alveolar / pathology
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Membrane Proteins / genetics
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Salmonella enterica / pathogenicity*
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Salmonella typhimurium / pathogenicity*
Substances
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Bacterial Proteins
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Caspase Inhibitors
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Membrane Proteins
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invasion protein B, Salmonella typhimurium