More about quantitative trait locus mapping with diallel designs

Genet Res. 2000 Apr;75(2):243-7. doi: 10.1017/s0016672399004358.

Abstract

We present a general regression-based method for mapping quantitative trait loci (QTL) by combining different populations derived from diallel designs. The model expresses, at any map position, the phenotypic value of each individual as a function of the specific-mean of the population to which the individual belongs, the additive and dominance effects of the alleles carried by the parents of that population and the probabilities of QTL genotypes conditional on those of neighbouring markers. Standard linear model procedures (ordinary or iteratively reweighted least-squares) are used for estimation and test of the parameters.

MeSH terms

  • Alleles*
  • Chromosome Mapping
  • Models, Genetic
  • Quantitative Trait, Heritable*