Attention-deficit/hyperactivity disorder: a neuropsychiatric disorder with childhood onset

Eur J Paediatr Neurol. 2000;4(2):53-62. doi: 10.1053/ejpn.1999.0263.


Attention-deficit/hyperactivity disorder (ADHD) is characterized by attentional problems such as hyperkinesia, restlessness and disturbances in timing. Environmental psychosocial factors interact with a genetic predisposition in causing measurable biological impairment. It is a common, persistent disorder of childhood that may change in manifestation with development from preschool through adult life. Untreated, it predisposes children to psychiatric and social pathology later in life. Unlike other psychiatric disorders of childhood, it can be successfully treated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Attention Deficit Disorder with Hyperactivity* / diagnosis
  • Attention Deficit Disorder with Hyperactivity* / etiology
  • Attention Deficit Disorder with Hyperactivity* / therapy
  • Brain / anatomy & histology
  • Brain / metabolism*
  • Central Nervous System Stimulants / therapeutic use
  • Child
  • Child, Preschool
  • Cognitive Behavioral Therapy / methods
  • Combined Modality Therapy
  • Culture
  • Diagnosis, Differential
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Methylphenidate / therapeutic use
  • Neurotransmitter Agents / metabolism*
  • Prognosis


  • Antidepressive Agents, Tricyclic
  • Central Nervous System Stimulants
  • Neurotransmitter Agents
  • Methylphenidate