Brain MRI lesions and atrophy are related to depression in multiple sclerosis

Neuroreport. 2000 Apr 27;11(6):1153-8. doi: 10.1097/00001756-200004270-00003.


It is unclear whether brain MRI lesions are associated with depression in multiple sclerosis (MS). Neurological dysfunction in depressed (n= 19) and non-depressed (n = 29) MS patients was rated by expanded disability status scale (EDSS). EDSS was weakly predictive of the presence of (p = 0.03) and severity of (p = 0.01) depression. After correcting for EDSS, the presence of depression was predicted by superior frontal and superior parietal hypointense TI lesions (p<0.01); the severity of depression was predicted by superior frontal, superior parietal and temporal TI lesions, lateral and third ventricular enlargement, and frontal atrophy (p<0.01). Depression was not related to bright T2 lesions or enhancement. We conclude that atrophy and cortical-subcortical disconnection due to frontal and parietal white matter destructive lesions may contribute to depression in MS.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atrophy / etiology
  • Atrophy / pathology
  • Demyelinating Diseases / etiology
  • Demyelinating Diseases / pathology
  • Depression / diagnosis
  • Depression / etiology*
  • Female
  • Frontal Lobe / pathology*
  • Frontal Lobe / physiopathology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications*
  • Multiple Sclerosis / pathology*
  • Neuropsychological Tests
  • Parietal Lobe / pathology*
  • Parietal Lobe / physiopathology
  • Predictive Value of Tests
  • Third Ventricle / pathology