The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation

Adv Cancer Res. 2000;79:39-90. doi: 10.1016/s0065-230x(00)79002-6.

Abstract

This article summarizes the structure, signal transduction and physiologic functions of the HGF/Met pathway, as well as its role in tumor growth, invasion, and metastasis. Moreover, it highlights recent studies indicating a role for the HGF/Met pathway in antigen-specific B-cell development and B-cell neoplasia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens / immunology
  • B-Lymphocytes / cytology*
  • Cell Differentiation
  • Cell Physiological Phenomena
  • Embryonic and Fetal Development
  • Epithelial Cells / cytology
  • Gene Expression Regulation, Developmental
  • Heparan Sulfate Proteoglycans / physiology
  • Hepatocyte Growth Factor / chemistry
  • Hepatocyte Growth Factor / physiology*
  • Humans
  • Leukemia, B-Cell / metabolism
  • Leukemia, B-Cell / pathology
  • Lymphoma, B-Cell / metabolism
  • Lymphoma, B-Cell / pathology
  • Mesoderm / cytology
  • Models, Molecular
  • Morphogenesis
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasm Proteins / physiology
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Protein Conformation
  • Proto-Oncogene Proteins c-met / chemistry
  • Proto-Oncogene Proteins c-met / physiology*
  • Rats
  • Signal Transduction*
  • Vertebrates / growth & development
  • Vertebrates / metabolism

Substances

  • Antigens
  • Heparan Sulfate Proteoglycans
  • Neoplasm Proteins
  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met