BMP, Wnt and Hedgehog signals: how far can they go?

Curr Opin Cell Biol. 2000 Apr;12(2):244-9. doi: 10.1016/s0955-0674(99)00082-4.


Wnt, Hedgehog and bone morphogenetic proteins function as either short-range or long-range signaling molecules depending on the tissue in which they are expressed. In the past year, filapodia-like cytoplasmic extensions, cell-surface proteogylcans and/or extracellular binding proteins have been identified that may enable these molecules to signal at a distance. Furthermore, recent studies suggest that variations in the signaling range of these molecules may be due to tissue-specific differences in intracellular processing or tissue-restricted expression of binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Bone Morphogenetic Proteins / metabolism*
  • Drosophila Proteins*
  • Endocytosis
  • Hedgehog Proteins
  • Humans
  • Proteins / metabolism*
  • Proteoglycans / metabolism
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction*
  • Trans-Activators*
  • Wnt1 Protein


  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • Hedgehog Proteins
  • Proteins
  • Proteoglycans
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Wnt1 Protein
  • wg protein, Drosophila