Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment

Synapse. 2000 Jun 15;36(4):342-4. doi: 10.1002/(SICI)1098-2396(20000615)36:4<342::AID-SYN11>3.0.CO;2-9.


Using in vivo extracellular single-cell recording and microiontophoresis, we compared the responsiveness of medial prefrontal cortex (mPFC) neurons (layers V-VI) to dopamine and glutamate in rats that had received repeated amphetamine or saline injections. Neurons from amphetamine-pretreated rats showed increased responsiveness to glutamate and decreased responsiveness to dopamine after three days of withdrawal, suggesting that the mPFC is transiently hyperexcitable during amphetamine withdrawal. Published 2000 Wiley-Liss, Inc.

MeSH terms

  • Amphetamine / administration & dosage*
  • Amphetamine / pharmacology
  • Animals
  • Dopamine / pharmacology*
  • Glutamic Acid / pharmacology*
  • Iontophoresis
  • Male
  • Neurons / drug effects*
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / drug effects*
  • Rats
  • Rats, Sprague-Dawley


  • Glutamic Acid
  • Amphetamine
  • Dopamine