"Normal-pressure" hydrocephalus. Relationship of clinical and radiographic findings to improvement following shunt surgery

JAMA. 1976 Feb 2;235(5):510-2. doi: 10.1001/jama.235.5.510.


Analysis of 25 patients who fulfilled clinical and radiographic criteria for the diagnosis of "normal pressure" hydrocephalus (NPH) demonstrated (1) a significant relationship between presence of motor signs with good outcome and absence of motor signs with poor outcome following ventricular shunting, (2) symptoms and signs of parkinsonism in 40% of patients in whom the diagnosis of NPH was made, and (3) no reliable relationship between radiographic measurements or cisternogram appearance and outcome following shunting. The clinical picture is the most important factor in selection of NPH patients for surgery.

MeSH terms

  • Adult
  • Aged
  • Ataxia / diagnosis
  • Basal Ganglia Diseases / diagnosis
  • Cerebral Ventriculography
  • Cerebrospinal Fluid Shunts*
  • Cisterna Magna
  • Evaluation Studies as Topic
  • Follow-Up Studies
  • Humans
  • Hydrocephalus / surgery*
  • Hydrocephalus, Normal Pressure / diagnostic imaging
  • Hydrocephalus, Normal Pressure / surgery*
  • Mental Disorders / diagnosis
  • Middle Aged
  • Parkinson Disease / diagnosis
  • Pneumoencephalography
  • Prognosis
  • Urinary Incontinence / diagnosis