Abstract
The actions of the amizon on the antioxidant activity and free radicaloformation level in the nuclear chromatin fractions of rat liver methan tetrachlorid intoxication was studied using the Fe(+2)-induction biochemiluminescence and microcalorimetry methods. The amizon genomoprotective effect on the chromatin transcriptionally active fraction was shown.
MeSH terms
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Animals
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Calorimetry
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Carbon Tetrachloride Poisoning / pathology
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Cell Nucleus / drug effects
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Cell Nucleus / metabolism
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Chemical and Drug Induced Liver Injury / pathology*
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Chromatin / chemistry
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Chromatin / drug effects*
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Chromatin / metabolism
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Liver / drug effects*
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Liver / metabolism
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Liver / ultrastructure
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Luminescent Measurements
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Male
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Protein Conformation
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Pyridines / pharmacology*
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Pyridinium Compounds
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Rats
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Rats, Wistar
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Transcription, Genetic
Substances
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Chromatin
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Pyridines
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Pyridinium Compounds
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enisamium