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. 2000 May 6;355(9215):1615-6.
doi: 10.1016/s0140-6736(00)02221-2.

Pharmacogenetic Prediction of Clozapine Response

Pharmacogenetic Prediction of Clozapine Response

M J Arranz et al. Lancet. .


We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/- 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.

Comment in

  • Pharmacogenetics of the clozapine response.
    Schumacher J, Schulze TG, Wienker TF, Rietschel M, Nöthen MM. Schumacher J, et al. Lancet. 2000 Aug 5;356(9228):506-7. doi: 10.1016/s0140-6736(05)74176-3. Lancet. 2000. PMID: 10981913 No abstract available.
  • Pharmacogenetics and antipsychotic drugs.
    Sher L. Sher L. Lancet. 2000 Jul 22;356(9226):342. doi: 10.1016/S0140-6736(05)73627-8. Lancet. 2000. PMID: 11071218 No abstract available.
  • Difficulties in replication of results.
    Arranz MJ, Munro J, Osborne S, Collier D, Kerwin RW. Arranz MJ, et al. Lancet. 2000 Oct 14;356(9238):1359-60. doi: 10.1016/s0140-6736(05)74275-6. Lancet. 2000. PMID: 11073057 No abstract available.

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