Pharmacogenetic Prediction of Clozapine Response

Lancet. 2000 May 6;355(9215):1615-6. doi: 10.1016/s0140-6736(00)02221-2.


We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/- 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Antipsychotic Agents / therapeutic use*
  • Clozapine / therapeutic use*
  • Genotype
  • Humans
  • Pharmacogenetics*
  • Polymorphism, Genetic*
  • Receptors, Serotonin / genetics*
  • Sensitivity and Specificity


  • Antipsychotic Agents
  • Receptors, Serotonin
  • Clozapine