Blood coagulation

Lancet. 2000 May 6;355(9215):1627-32. doi: 10.1016/S0140-6736(00)02225-X.


Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding conformation. Heparin stimulates the activity of antithrombin, a serine-protease inhibitor. Analysis of knock-out mice has shown the relative importance of the coagulation factors in vivo. Gene therapy may soon be a therapeutic option for inherited deficiencies of factors VIII and IX.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Coagulation / physiology*
  • Hemophilia A / physiopathology
  • Hemophilia B / physiopathology
  • Hemorrhagic Disorders / physiopathology*
  • Humans
  • Protein C / physiology
  • Protein S / physiology
  • Thrombin / physiology
  • Venous Thrombosis / physiopathology
  • von Willebrand Diseases / physiopathology


  • Protein C
  • Protein S
  • Thrombin