PvuII polymorphisms of the estrogen receptor alpha and bone mineral density in healthy southern Chinese women

Calcif Tissue Int. 2000 Jun;66(6):405-8. doi: 10.1007/s002230010082.


The association between PvuII polymorphisms of the estrogen receptor alpha (ERalpha) gene and total as well as regional bone mineral density (BMD) in healthy Chinese women (n = 182) was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), where P indicated the absence and p the presence of PvuII restriction sites. Subjects with PP genotype had significantly higher BMD at the thoracic spine and ribs (both P < 0.05) when compared with those with Pp and pp genotypes. Although PP genotype had slightly higher BMD values at the lumbar spine L2-L4 region and hip by 8% and 7%, respectively, the results failed to reach statistical significance. After adjusting for age, height, weight, and years since menopause, PP genotype had higher BMD at the left (P < 0.02) and right (P < 0.05) rib region but not at the thoracic spine (P = 0.056). Analyzing the premenopausal subjects alone (n = 64) revealed that subjects with PP genotype had higher adjusted BMD at the right rib region (P < 0.05). When only the postmenopausal women (n = 118) were analyzed, the adjusted BMD of the PP genotype at the thoracic spine was significantly higher (P < 0.05) than the other two groups. In conclusion, estrogen receptor gene has a role in determining bone mass but the clinical impact on its own is probably small.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asians / genetics*
  • Bone Density / genetics*
  • China
  • Estrogen Receptor alpha
  • Female
  • Genotype
  • Hip / diagnostic imaging
  • Humans
  • Middle Aged
  • Polymorphism, Genetic
  • Polymorphism, Restriction Fragment Length
  • Postmenopause
  • Premenopause
  • Radiography
  • Receptors, Estrogen / genetics*
  • Ribs / diagnostic imaging
  • Spine / diagnostic imaging


  • Estrogen Receptor alpha
  • Receptors, Estrogen