Increased CSF levels of nerve growth factor in patients with Alzheimer's disease

Neurology. 2000 May 23;54(10):2009-11. doi: 10.1212/wnl.54.10.2009.

Abstract

The authors quantitated CSF levels of nerve growth factor (NGF) in patients with AD, nondemented control subjects (CTR), and age-matched patients with major depression (DE). CSF levels of NGF were markedly higher in the AD group than in both the CTR and DE groups (p < 0.01 and p < 0.001). Increased CSF levels of NGF in AD patients may reflect reported accumulation of NGF in the AD brain and may constitute a candidate marker for clinical diagnosis and therapeutic monitoring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / cerebrospinal fluid
  • Alzheimer Disease / diagnosis*
  • Biomarkers / cerebrospinal fluid*
  • Depressive Disorder, Major / cerebrospinal fluid
  • Depressive Disorder, Major / diagnosis
  • Diagnosis, Differential
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Growth Factor / cerebrospinal fluid*
  • Predictive Value of Tests

Substances

  • Biomarkers
  • Nerve Growth Factor