Coexistent lymphoid interstitial pneumonia, pernicious anemia, and agammaglobulinemia

Arch Intern Med. 1976 Feb;136(2):213-6.


Immunologic factors have been incriminated in the pathogenesis of lymphoid interstitial pneumonia. The discovery of a patient with coexistent lymphoid interestitial pneumonia, pernicious anemia, and common variable hypogammaglobulinemia focused attention on the possible autoimmune nature of this pulmonary disease. Extensive immunologic studies demonstrated a noticeably impaired bonemarrow-dependent (B cell) system and intact thymus-dependent (T cell) system. No evidence of humoral or cellular hypersensitivity to homologous lung determinants was found.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Agammaglobulinemia / complications*
  • Agammaglobulinemia / immunology
  • Anemia, Pernicious / complications*
  • Anemia, Pernicious / immunology
  • Autoantibodies / analysis
  • Autoimmune Diseases / complications*
  • B-Lymphocytes / immunology
  • Female
  • Humans
  • Immunity, Cellular
  • Lung / immunology
  • Middle Aged
  • Pulmonary Fibrosis / complications*
  • Pulmonary Fibrosis / immunology
  • T-Lymphocytes / immunology


  • Autoantibodies