Abstract
The immune response was evaluated in 11 children with Streptococcus pneumoniae and in 9 children with Moraxella catarrhalis otitis media. The age of the children had a range of 4-32 months. The mean IgG, IgM, and IgA antibody responses to surface protein A (PspA) of S. pneumoniae in sera from children at the acute and convalescent stages were 4864 versus 5831 ng/mL, P<.05, 1075 versus 3752 ng/mL, P<.05, and 67 versus 93 ng/mL, nonsignificant (NS), respectively. The mean IgG, IgM, and IgA antibody responses to the high-molecular-weight outer membrane protein (UspA) of M. catarrhalis in sera from children at acute and convalescent stages were 710 versus 935 mg/mL, NS; 1895 versus 2646 ng/mL, NS; and 121 versus 204 ng/mL, P<.05, respectively. These data show that PspA and UspA are immunogenic in children after otitis media.
MeSH terms
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Acute Disease
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Antibodies, Bacterial / blood*
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Antigens, Bacterial / immunology
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Bacterial Outer Membrane Proteins / immunology*
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Bacterial Proteins / immunology*
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Child, Preschool
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Convalescence
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunoglobulin A / blood
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Infant
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Male
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Molecular Weight
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Moraxella catarrhalis / immunology*
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Neisseriaceae Infections / blood
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Neisseriaceae Infections / immunology*
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Otitis Media / blood
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Otitis Media / immunology
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Otitis Media / microbiology*
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Pneumococcal Infections / blood
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Pneumococcal Infections / immunology*
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Prospective Studies
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Streptococcus pneumoniae / immunology*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin M
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pneumococcal surface protein A
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OMPA outer membrane proteins